MIDS Capstone Project Fall 2023
AntibodyGPT: A Fine-Tuned GPT for De Novo Therapeutic Antibodies
Team members:
What are antibodies?
Antibodies are proteins that bind to a target protein (called an antigen) in order to mount an immune response.
They are incredibly safe and effective therapeutics against infectious diseases, cancer, and autoimmune disorders.
Why aren’t there more antibodies on the market?
Current antibody discovery methods require a lot of capital, expertise, and luck.
Generative AI opens up the possibility of moving from a paradigm of antibody discovery to antibody generation.
However, work is required to translate the advances of LLMs to the realm of drug discovery.
What is AntibodyGPT?
A fine-tuned GPT language model that researchers can use to rapidly generate functional, diverse antibodies for any given target sequence
Key Features
- Rapid generation
- Only requires target sequence
- Outputs diverse, human-like antibodies
Course
Data Science 210. Capstone, Fall 2023
